timi天美传孟若羽

团队介绍：

本团队一直从事儿童脑发育疾病的机制研究。在国内外共发表论文60余篇，其中以第一/通信作者在Br J Pharmacol，Glia，Epilepsia等国际期刊上发表论文20余篇，主编专_x0008_著1部，参编专_x0008_著2部，作为副主编参编学术期刊专_x0008_刊1期，获批专_x0008_利2项。

项目情况：

曾经或正在主持国家自然科学基金面上项目1项，国家自然科学基金青年项目1项，北京市自然科学基金面上项目1项，并参与多项国家级重点项目，包括国家重点研发计划2项，国家自然科学基金联合基金项目1项。

招生信息（拟招生的研究方向）：

儿科神经方向的硕士生

科研项目：

摆1闭国家自然科学基金区域创新发展联合基金，鲍22础20339，儿童罕见遗传性癫痫的新发病机制及新治疗策略研究，2023/1-2026/12，255万，参与；

摆2闭国家自然科学基金面上项目，81234567，中药甘草治疗碍颁狈罢1基因功能增强型突变所致癫痫的机制研究，2022/1-2025/12，55万，主持；

摆3闭北京市自然科学基金面上项目，7212109，碍颁狈罢1基因突变所致癫痫的精准治疗研究，2021/1-2023/12，20万，主持；

摆4闭国家重点研发计划，2020驰贵础0804000，儿童发育异常的遗传调控研究，2020/12-2025/11，2204万，参与；

摆5闭国家自然科学基金青年项目，81601131，钾离子通道碍颁狈罢1突变的致痫机制研究，2017/1-2019/12，17万，主持；

摆6闭国家重点研发计划，2016驰贵颁1306200，儿童脑发育障碍的早期识别和综合干预，2016/9-2020/12，579万，参与。

代表性研究成果：

1.Zhang J, XiangWei W, Zhang F, Yi H, Yan W, Li X, Gao K#, Jiang Y#. Tamibarotene promotes differentiation of neuroblastoma SH-SY5Y cells into neurons, which is associated with activation of the PI3K/AKT signaling pathway. BMC Neurosci. 2025 Jul 15;26(1):41. doi: 10.1186/s12868-025-00962-8. PMID: 40665231; PMCID: PMC12265314.（论著，Q3，IF=2.3，共同责任）

2.Liu N, Lin Z, Song H, Cai A, Li X, Zhang J, Chang D, Ji T, Wu Y, Huang Z, Jiang Y#, Gao K#. Functional evaluation of a rat model of KCNT1-related epilepsy. Epilepsy Res. 2025 May 17;216:107589. doi: 10.1016/j.eplepsyres.2025.107589. Epub ahead of print. PMID: 40460702.（论著，Q3，IF=2，共同责任）

3.Gao K#, Cheung-Hoi Yu A#. Glutamate, a Key for Astrocytes to Participate in Brain Function and Diseases. Neurochem Res. 2025 May 15;50(3):166. doi: 10.1007/s11064-025-04418-7. PMID: 40372498.2.（Review，Q2，IF=3.7，第一作者，共同责任）

4.Zhang J, Li X, Zhang F, Chu H, Wang J, Wu Y, Gao K#, Jiang Y#. Spatiotemporal Expression of IRS-1 During Brain Development and its Role in Neural Stem Cell Differentiation. Neuromolecular Med. 2025 May 2;27(1):32. doi: 10.1007/s12017-025-08853-1. PMID: 40314831.（论著，Q2，IF=3.3，共同责任）

5.Zhang F,* Gao K*, Zhang J, Li S, Li Y, Wang J, Wu Y, Jiang Y, Wu C. Bexarotene Promotes Neuroblastoma SH-SY5Y Cell Differentiation to Mature Neurons with Decreased Proliferation. Mol Neurobiol. 2025 Apr 14. doi: 10.1007/s12035-025-04888-4. Epub ahead of print. PMID: 40229457.（论著，Q1，IF=4.6，共同第一）

6.Di C*, Wu T*, Gao K*, Li N, Song H, Wang L, Sun H, Yi J, Zhang X, Chen J, Shah M#, Jiang Y#, Huang Z#. Carvedilol inhibits neuronal hyperexcitability caused by epilepsy-associated KCNT1 mutations. Br J Pharmacol. 2025 Jan;182(1):162-180. doi: 10.1111/bph.17360. Epub 2024 Oct 6. PMID: 39370580.（论著，Q1，IF=6.8，共同第一，第一作者单位不是timi天美传孟若羽）

7.Liu W*, Gao K*, Du X, Wen S, Yan H, Wang J, Wang Y, Song C, Lin L, Ji T, Gu W, Jiang Y. SPOUT1 variants associated with autosomal-recessive developmental and epileptic encephalopathy. Acta Epileptol. 2024 Dec 15;6(1):42. doi: 10.1186/s42494-024-00185-0. PMID: 40217412; PMCID: PMC11960386.（论著，Q4，IF=1.2，共同第一）

8.Li X, Gao K*, Li Y, Zhang Y, Zhang H, Jiang Y. Effective treatment of NR2F1-related epilepsy with perampanel. Acta Epileptol. 2024 Jan 24;6(1):3. doi: 10.1186/s42494-023-00145-0. PMID: 40217317; PMCID: PMC11960385.（论著，Q4，IF=1.2，共同第一）

9.Li X, Wang T, Liu N, Cai A, Zhang J, Zhang F, Liu Q, Wang J, Wu Y#, Gao K#, Jiang Y#. Focal cortical dysplasia II caused by brain somatic mutation of IRS-1 is associated with ERK signaling pathway activation. Cereb Cortex. 2024 Jun 4;34(6):bhae227. doi: 10.1093/cercor/bhae227. PMID: 38836287.（论著，Q2，IF=2.9，共同责任）

10.Liu N*, Li J*, Gao K*, Perszyk RE, Zhang J, Wang J, Wu Y, Jenkins A, Yuan H, Traynelis SF, Jiang Y. De novo CLPTM1 variants with reduced GABAA R current response in patients with epilepsy. Epilepsia. 2023 Nov;64(11):2968-2981. doi: 10.1111/epi.17746. Epub 2023 Aug 30. PMID: 37577761; PMCID: PMC10840799.（论著，Q1，IF=6.6，共同第一）

11.Zhang H*, Gao K*, Wang S, Zhang YH, Yang ZX, Wu Y, Jiang YW#. PACS gene family-related neurological diseases: limited genotypes and diverse phenotypes. World J Pediatr. 2023 Jan 16. doi: 10.1007/s12519-022-00652-z. Epub ahead of print. PMID: 36645641.（论著，Q1，IF=6.1，共同第一）

12.Cai A*, Liu N, Lin Z, Li X, Wang J, Wu Y, Gao K#, Jiang Y#. In Vitro Effects of Acitretin on Human Neuronal SH-SY5Y Cells. Neurochem Res. 2023 Jan;48(1):72-81. doi: 10.1007/s11064-022-03716-8. Epub 2022 Aug 20. PMID: 35987975; PMCID: PMC9822877.（论著，Q2，IF=3.7，共同责任）

13.Cai A*, Lin Z*, Liu N, Li X, Wang J, Wu Y, Gao K#, Jiang Y#. Neuroblastoma SH-SY5Y Cell Differentiation to Mature Neuron by AM580 Treatment. Neurochem Res. 2022 Dec;47(12):3723-3732. doi: 10.1007/s11064-022-03730-w. Epub 2022 Sep 6. PMID: 36066699; PMCID: PMC9718880.（论著，Q2，IF=3.7，共同责任）

14.Gao K*, Wu C*, Li Y, Lu J#, Jiang Y#. Transcriptome Analysis Reveals the Anti-Tumor Mechanism of Eucalyptol Treatment on Neuroblastoma Cell Line SH-SY5Y. Neurochem Res. 2022 Dec;47(12):3854-3862. doi: 10.1007/s11064-022-03786-8. Epub 2022 Nov 4. Erratum in: Neurochem Res. 2022 Nov 21;: PMID: 36331666; PMCID: PMC9718713.（论著，Q2，IF=3.7，共同第一）

15.Lin Z*, Sang T, Yang Y, Wu Y, Dong Y, Ji T, Zhang Y, Wu Y, Gao K#, Jiang Y#. Efficacy of Anti-seizure Medications, Quinidine, and Ketogenic Diet Therapy for KCNT1-Related Epilepsy and Genotype-Efficacy Correlation Analysis. Front Neurol. 2022 Jan 18;12:834971. doi: 10.3389/fneur.2021.834971. PMID: 35116000; PMCID: PMC8804090.（论著，Q2，IF=2.7，共同责任）

16.Lin Z*, Li J, Ji T, Wu Y, Gao K#, Jiang Y#. ATP1A1 de novo Mutation-Related Disorders: Clinical and Genetic Features. Front Pediatr. 2021 Apr 21;9:657256. doi: 10.3389/fped.2021.657256. PMID: 33968856; PMCID: PMC8098805.（论著，Q2，IF=2.1，共同责任）

17.Zhang Z*, Gao K*, Liu Q*, Zhou J, Li X, Lang N, Liu M, Wang T, Zhang J, Wang H, Dong Y, Ji T, Wang S, Liu X, Jiang Y#, Cai L#, Wu Y#. Somatic variants in new candidate genes identified in focal cortical dysplasia type II. Epilepsia. 2020 Apr;61(4):667-678. doi: 10.1111/epi.16481. Epub 2020 Mar 26. PMID: 32216069. （论著，Q1，IF=6.6，共同第一）

18.Gao K, Lin Z, Wen S, Jiang Y#. Potassium channels and epilepsy. Acta Neurol Scand. 2022 Dec;146(6):699-707. doi: 10.1111/ane.13695. Epub 2022 Oct 12. PMID: 36225112.（综述, Q2, IF=2.9，单独第一）

19.Gao K, Zhan JS, Yu ACH#. The Miracle "Glue" Cell. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS. 2022, 49(11):2083-2086. DOI: 10.16476/j.pibb.2022.0485。（编者按, Q4, IF=0.3，单独第一）

20.Gao K, Zhang Y, Zhang L, Kong W, Xie H, Wang J, Wu Y, Wu X, Liu X, Zhang Y, Zhang F, Yu AC, Jiang Y. Large De Novo Microdeletion in Epilepsy with Intellectual and Developmental Disabilities, with a Systems Biology Analysis. Adv Neurobiol. 2018;21:247-266. doi: 10.1007/978-3-319-94593-4_9. PMID: 30334225.（Chapter）

21.Gao K, Tankovic A, Zhang Y, Kusumoto H, Zhang J, Chen W, XiangWei W, Shaulsky GH, Hu C, Traynelis SF, Yuan H, Jiang Y. A de novo loss-of-function GRIN2A mutation associated with childhood focal epilepsy and acquired epileptic aphasia. PLoS One. 2017 Feb 9;12(2):e0170818. doi: 10.1371/journal.pone.0170818. PMID: 28182669; PMCID: PMC5300259.（论著，Q1，IF=2.9，共同第一）

22.Gao K, Wang CR, Jiang F, Wong AY, Su N, Jiang JH, Chai RC, Vatcher G, Teng J, Chen J, Jiang YW, Yu AC. Traumatic scratch injury in astrocytes triggers calcium influx to activate the JNK/c-Jun/AP-1 pathway and switch on GFAP expression. Glia. 2013 Dec;61(12):2063-77. doi: 10.1002/glia.22577. Epub 2013 Oct 7. PMID: 24123203.（论著，Q1，IF=5.4，共同第一）