timi天美传孟若羽

团队介绍：

依托杨敏教授领衔的国家级血管外科平台，本课题组专_x0008_注外周动脉疾病（笔础顿）发病机制、精准诊断与微创治疗研究。课题组现由1名博士后、2名博士研究生和4名硕士研究生组成，形成了一支结构合理、充满活力的研究梯队。团队近叁年研究生人均产出厂颁滨论文2篇，并主持国家自然科学基金等4项省部级以上科研项目，为团队成员提供充足的科研经费和先进的实验平台。本团队注重学术传承与创新，营造了积极向上的科研氛围。

项目情况：

课题组目前开展的项目有：

周围动脉疾病的生物学标志物研究

周围动脉疾病的发病机制

动脉粥样硬化性肾动脉狭窄的预测因素探索与模型构建

干细胞内皮分化及在周围动脉疾病中的应用

招生信息（拟招生的研究方向）：

临床医学专_x0008_业（外科方向优先）

对血管介入治疗或血管外科的科研或临床工作有浓厚兴趣

科研项目：

负责人主持国家自然科学基金项目1项，并作为核心成员参与北京市自然科学基金、首都卫生发展科研专_x0008_项及国家卫生健康委科研项目等多项省部级课题。这些科研项目为本人开展外周动脉疾病（笔础顿）创新研究提供了坚实的科研经费支持和研究平台保障。

代表性研究成果：

1: Zhang B, He R, Yao Z, Li P, Niu G, Yan Z, Zou Y, Tong X, Yang M. Exploring Causal Relationships between Circulating Inflammatory Proteins and Thromboangiitis Obliterans: A Mendelian Randomization Study. Thromb Haemost. 2024 Nov;124(11):1075-1083. doi: 10.1055/s-0044-1786809. Epub 2024 May 24. PMID: 38788766; PMCID: PMC11518616.

2: Zhang B, Niu G, Yan Z, Zou Y, Tong X, Yang M. Midterm outcomes of endovascular treatment with bare metal stents for Leriche syndrome patients. Interact Cardiovasc Thorac Surg. 2021 Jan 1;32(1):83-88. doi:10.1093/icvts/ivaa223. PMID: 33221834; PMCID: PMC8906679.

3: Yao Z, Zhang B, Niu G, Yan Z, Tong X, Zou Y, Yang M. Subunits of C1Q Are Associated With the Progression of Intermittent Claudication to Chronic Limb-Threatening Ischemia. Front Cardiovasc Med. 2022 Apr 1;9:864461. doi:10.3389/fcvm.2022.864461. PMID: 35433866; PMCID: PMC9010542.

4: Zhang B, Yao Z, Li P, Niu G, Yan Z, She K, Cheng G, Yang M. Causal Relationships of Circulating Inflammatory Proteins and Portal Vein Thrombosis: A Mendelian Randomization Study. Semin Thromb Hemost. 2025 Apr;51(3):272-278. doi:10.1055/s-0044-1790259. Epub 2024 Sep 18. PMID: 39293485.

5: Yao Z, Zhang B, Niu G, Yan Z, Tong X, Zou Y, Li Y, Yang M. Neutrophil Infiltration Characterized by Upregulation of S100A8, S100A9, S100A12 and CXCR2 Is Associated With the Co-Occurrence of Crohn's Disease and Peripheral Artery Disease. Front Immunol. 2022 Jun 20;13:896645. doi: 10.3389/fimmu.2022.896645. PMID: 35795659; PMCID: PMC9251382.

6: Zhang B, Yao Z, Niu G, Yan Z, Zou Y, Tong X, Yu X, Ma B, Liu B, Ye Z, Yang M. Role of the Global Limb Anatomic Staging System in predicting outcomes of chronic limb-threatening ischemia in patients treated by drug-coated balloons. Quant Imaging Med Surg. 2023 Mar 1;13(3):1350-1359. doi: 10.21037/qims-22-715. Epub 2022 Nov 30. PMID: 36915348; PMCID: PMC10006147.

7: Lin Z, Zhang B, Lin L, Wang R, Niu G, Yan Z, Zou Y, Tong X, Qiu J, Yang M. Prediction of Split Renal Function Improvement After Renal Artery Stenting by Blood Oxygen Level-Dependent Magnetic Resonance Imaging. Front Cardiovasc Med. 2022 Feb 28;9:793777. doi: 10.3389/fcvm.2022.793777. PMID: 35295270; PMCID: PMC8918535.

8: Zhang B, Yao Z, Gao W, Wang C, Kong H, Zhang J, Yang M. Dynamic R2' Imaging can Be a Biomarker for Diagnosing and Staging Early Acute Kidney Injury in Animals. Front Med (Lausanne). 2021 Dec 24;8:775042. doi: 10.3389/fmed.2021.775042. PMID: 35004744; PMCID: PMC8739497.

9: Lin Z, Zhang B, Lin L, Zou Y, Qiu J, Yang M. Blood Oxygen Level Dependent Magnetic Resonance Imaging To Predict Split Renal Function Improvement After Renal Artery Stenting. Eur J Vasc Endovasc Surg. 2022 Apr;63(4):659-660. doi: 10.1016/j.ejvs.2021.12.044. Epub 2022 Mar 10. PMID: 35282999.

10: Zhang B, Wang Y, Wang C, Wang H, Kong H, Zhang J, Zou Y, Yang M. Comparison of blood oxygen level-dependent imaging and diffusion-weighted imaging in early diagnosis of acute kidney injury in animal models. J Magn Reson Imaging. 2019 Sep;50(3):719-724. doi: 10.1002/jmri.26617. Epub 2019 Jan 11. PMID: 30635951.

11: Zhang B, Yang M, Zou Y. Plaque distribution in common femoral artery bifurcations, based on multi-slice computed tomography assessment. Clin Invest Med. 2017 Dec 17;40(6):E228-E234. doi: 10.25011/cim.v40i6.29123. PMID: 29256388.

12: Zhang B, Yang M, He T, Li X, Gu J, Zhang X, Dai X, Li X, Lu X, Lang D, Hu H, Chen X, Yang B, Gu H, Zhang X, Zou Y. Twelve-Month Results From the First-in-China Prospective, Multi-Center, Randomized, Controlled Study of the FREEWAY Paclitaxel-Coated Balloon for Femoropopliteal Treatment. Front Cardiovasc Med. 2021 Sep 10;8:686267. doi: 10.3389/fcvm.2021.686267. PMID: 34568443; PMCID:PMC8460758.

13: Wang C, Zhang B, Wang H, Kong H, Gao F, Wang X, Yang M, Zhang J. A feasibility study of using noninvasive renal oxygenation imaging for the early assessment of ischemic acute kidney injury in an embolization model. Magn Reson Imaging. 2019 Nov;63:178-184. doi: 10.1016/j.mri.2019.08.027. Epub 2019 Aug 16. PMID: 31425814.