timi天美传孟若羽

团队介绍：

timi天美传孟若羽神经内科神经免疫及神经肌肉病专_x0008_业团队。团队成员包括timi天美传孟若羽 神经内科 袁云教授、王朝霞教授、高枫教授、郝洪军主任技师、刘冉教授等。研究团队长期致力于神经免疫病以及神经肌肉病的诊治和基础研究。

项目情况：

课题组主要研究神经免疫病及神经肌肉病的临床诊治、发病机制及干预策略，研究方向包括：1）基于重症肌无力队列，研究重症肌无力，尤其是痴尝翱惭骋临床、发病机制及治疗策略。2）基于皮肌炎队列，尤其是狈齿笔2抗体阳性皮肌炎细胞和动物模型构建、利用多组学手段进行发病机制以及治疗药物研发等。

招生信息（拟招生的研究方向）：

神经免疫以及神经肌肉病

科研项目：

国家自然科学基金“皮肌炎中游离线粒体顿狈础激活肠骋础厂-厂罢滨狈骋通路介导滨型干扰素上调的机制研究”主持

国家自然科学基金“以治疗达标为导向的重症肌无力个体化免疫治疗：结合生物标志物的 疗效评估与预测”参与

代表性研究成果：

1. Wang Y, Yuan Q, Zhao Y, Gang Q, Ma Y, Hao H, Gao F, Deng J, Zhang W, Wang Z, Yuan Y, Zheng Y. The immune response to the dermatomyositis-specific autoantigen nuclear matrix protein 2 can result in experimental autoimmune myositis. Ann Rheum Dis. 2025 May 8:S0003-4967(25)00810-6. 责任作者

2. Zhang Z, Gao F, Sun W, Wang Z, Zheng Y. Cortical ribbon sign in AMPAR antibody-associated encephalitis mimicking Creutzfeldt-Jakob disease. Neurol Sci. Published online October 30, 2024. doi:10.1007/s10072-024-07850-9 责任作者

3. Wang Y, Zhao Y, Gang Q, Hao H, Gao F, Deng J, Wang Z, Zhang W, Yuan Y, Zheng Y. Circulating cell-free DNA promotes inflammation in dermatomyositis patients with anti-NXP2 antibodies  via the cGAS/STING pathway. Rheumatology (Oxford). 2025 Apr 1;64(4):2272-2281.共同责任作者

4. Chen Y, Zhang W, Lv H, Wang Z, Hao H, Yuan Y, Zheng Y. Pathological findings with vacuoles in anti-mitochondrial antibody-positive inflammatory myopathy. BMC Musculoskelet Disord. 2024 Apr 2;25(1):257. doi: 10.1186/s12891-023-06941-6. PMID: 38566087; PMCID: PMC10985968.(责任作者)

5. Li, J., Zheng, Y., Zhao, Y., Qi, K., Lin, G., Liu, R., Hao, H., Wang, Z., Yuan, Y., & Gao, F. (2024). COVID-19 in patients with myasthenia gravis: a single-center retrospective study in China. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 45(7), 2969–2976.（共同责任作者）

6. Zheng, Y., Zhao, Y., Hao, H., Wang, Z., Gao, F., Zhang, W., & Yuan, Y. (2023). What should we expect when two myositis-specific antibodies coexist in a patient. European journal of medical research, 28(1), 429. https://doi.org/10.1186/s40001-023-01363-5

7. Zheng Y, Yuan X, Zhang C, Liu R, Jin H, Hao H, Li F, Zhao Y, Yuan Y, Wang Z and Gao F (2022) Efficacy and Safety of Tacrolimus Therapy for a Single Chinese Cohort With Very-Late-Onset Myasthenia Gravis. Front. Neurol. 13:843523. doi: 10.3389/fneur.2022.843523

8. Zhang, W., Zheng, Y., Wang, Y., Xiong, H., Que, C., Zhang, X., Zhu, Y., Zhao, Y., Yu, M., Meng, L., Lv, H., Zhang, W., Hao, H., Xiao, J., Yuan, Y., & Wang, Z. (2022). Thigh MRI in antisynthetase syndrome, and comparisons with dermatomyositis and immune-mediated necrotising myopathy. Rheumatology (Oxford, England), keac269. Advance online publication.（共同一作）

9. Zheng, Y., Wang, X., Zhao, H., Jiang, Y., Zhu, Y., Chen, J., Sun, W., Wang, Z., & Sun, Y. (2022). The "Black Straight-Line Sign" in the Putamen in Diffusion-Weighted Imaging: A Potential Diagnostic MRI Marker for Multiple System Atrophy. Frontiers in neurology, 13, 890168

10. Zheng Y, Luo J, Jin H, Liu R, Hao H, Gao F. Myasthenia gravis associated with renal cell carcinoma: a paraneoplastic syndrome or just a coincidence. BMC Neurol. 2021 Jul 12;21(1):277. doi: 10.1186/s12883-021-02311-8. PMID: 34253185.

11. Zheng Y, Li W, Du J, et al. The trefoil with single fruit sign in muscle magnetic resonance imaging is highly specific for dystrophinopathies. Eur J Radiol. 2015;84(10):1992-1998.

12. Zheng Y, Liu L, Wang L, et al. Magnetic resonance imaging changes of thigh muscles in myopathy with antibodies to signal recognition particle. Rheumatology (Oxford). 2015;54(6):1017-1024.

13. Mei Yang*; Yiming Zheng* (共同一作); Zhiying Xie; Zhaoxia Wang; Jiangxi Xiao; Jue Zhang; Yun Yuan, A Deep Learning model for diagnosing Dystrophinopathies on Thigh Muscle MRI images，BMC Neurology NURL-D-20-00464R3

14.Zhong H*, Zheng Y*（共同一作）, Zhao Z, Lin P, Xi J, Zhu W, Lin J, Lu J, Yu M, Zhang W, Lv H, Yan C, Hu J, Wang Z, Lu J, Zhao C, Yuan Y, Luo S. Molecular landscape of CAPN3 mutations in limb-girdle muscular dystrophy type R1: from a Chinese multicentre analysis to a worldwide perspective. J Med Genet. 2020 Sep 29:jmedgenet-2020-107159